
About Osteoarthritis
What is Osteoarthritis?
Osteoarthritis (OA) is the most common type of arthritis, also known as degenerative joint disease, for which there is no cure. It is a common, chronic, progressive musculoskeletal disorder.
80% of the population over 65 years old has radiographic evidence of OA.1 Patients suffering from OA often face chronic pain that worsens over time. Most commonly affecting middle-aged and older people, OA can range from very mild to very severe.
Powerful New Treatment
for the Pain of Osteoarthritis
Is Cingal right for you?
Anika’s Cingal is the only next-generation non-opioid OA pain management product that is registered and approved for sale in 35+ countries.
HA is vital for maintaining the function and elasticity of the synovial fluid. Cingal is designed to supplement the reduced amount of natural hyaluronic acid found in the synovial fluid in osteoarthritic knee joints, while the steroid component treats inflammation and provides fast pain relief within days of injection.
The high concentration and total delivered dose of hyaluronic acid in Cingal combined with a well-established corticosteroid creates a fast acting high viscosity solution that helps provide cushioning from normal physical activities like walking and biking.

The Science Behind Cingal
Cingal® is uniquely formulated as a hyaluronic acid (HA) viscosupplement plus corticosteroid combination injection.
“Only Cingal® works by combining a fast-acting steroid with a long-lasting viscous supplement in a single, convenient injection.”

Key Features and Benefits
- Cingal has demonstrated, in key clinical studies (2014), fast and long-lasting relief from knee OA pain
- The steroid provides immediate relief within days of injection
- The HA provides relief that lasts up to 6 months
- Convenient treatment with a single injection
- High-purity, non-animal sourced HA
- Safe and effective, even with repeated injections

Next generation, non-opioid OA pain management
First and only approved* combination hyaluronic acid (HA) plus steroid treatment for the pain of osteoarthritis
Fast acting pain relief
Steroid provides rapid short-term pain relief within days of injection
Long lasting pain relief
HA viscosupplement provides long lasting pain relief through 6 months
Convenient single-injection treatment
Simple one injection procedure that can be done in the convenience of a physician’s office
Natural Solution
Highly concentrated, non-animal based HA produced from bacterial fermentation
Safe and Effective
Strong safety profile in both an initial injection as well as a repeat injection
Clinically Proven
Unprecedented rapid and long lasting knee pain relief demonstrated across three Phase III Cingal clinical trials

Cingal® delivers fast acting and long lasting relief from the pain of osteoarthritis. Cingal is helping patients all over the world to once again enjoy daily physical activities with reduced pain.
The Patient ExperienceFast Acting. Long Lasting.
Cingal is clinically proven to deliver statistically significant knee pain relief, providing faster pain relief compared to ha alone, and demonstrating superior long lasting pain relief compared to saline (control).
The Cingal Difference
Next Generation Osteoarthritis Treatment
HA is vital for maintaining the function and elasticity of the synovial fluid. Cingal is designed to supplement the reduced amount of natural hyaluronic acid found in the synovial fluid in osteoarthritic knee joints, while the steroid component treats inflammation and provides fast pain relief within days of injection.
The high concentration and total delivered dose of hyaluronic acid in Cingal combined with a well-established corticosteroid creates a fast acting high viscosity solution that helps provide cushioning from normal physical activities like walking and biking.
